How much glucosamine does a woman need
The cost of these and other non-vitamin supplements and herbal remedies is close to 21 billion dollars per year. They are touted not only as arthritis pain relievers but also as treatments to prevent joint disease. The case for these supplements protecting joint health or preventing arthritis is similarly weak. The study was stopped early for an unusual reason — those taking the supplement actually reported worse symptoms than those taking a placebo.
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What Is Glucosamine?
As the only practitioner of complementary and alternative medicine in a multicenter practice in central Pennsylvania an area not known, at least in terms of its medical community, for embracing change , it can be frustrating to try to educate my colleagues on the usefulness of supplements in maintaining optimal health.
Osteoarthritis OA is one of the most common and debilitating diseases to afflict middle-aged and elderly people.
Despite decades of research on the origins and characteristics of OA, scientists are still not sure what causes this debilitating condition—and there is still no cure. Remarkably, there is not even a drug that does anything more than relieve the pain of OA.
Pain relief is a huge plus, of course, but it does nothing to improve the underlying condition. Victims of OA have progressive degeneration of the joints.
Up to the age of about 50, OA of the knees is more prevalent in men than in women; in the more elderly population, however, the incidence of knee OA increases more rapidly in women.
Both men and women with severe OA suffer not only from pain and stiffness caused by joint destruction, but also from significant loss of mobility, which can greatly interfere with every aspect of their lives. Some NSAIDs, such as aspirin, acetaminophen, ibuprofen, and naproxen, are sold over-the-counter, but other, more powerful ones are prescription drugs that can be quite expensive.
Although they can help ease the inflammation and pain of OA, they do nothing to retard the progression of this disabling disease. In addition, NSAIDs can have significant and potentially life-threatening side effects, such as gastrointestinal bleeding. The answer, sadly, is very little. Physical therapy can be used to try to regain some of the mobility lost to the ravages of joint degradation, and surgery is sometimes used to replace joints that have been severely damaged.
A relatively new therapy entails a series of injections of a lubricating fluid directly into the knee joint. These methods are of limited use, however, and can be very expensive—and, as with painkillers, they do not affect the disease itself.
One of the Holy Grails of conventional medicine is to find a drug that can stop the progression of OA. These are safe, effective, natural compounds that are used as nutritional supplements. Although glucosamine and chondroitin are helpful in relieving the symptoms of OA, their primary benefit lies in improving the structure of the affected joints, i. If cartilage becomes worn or degraded, however, as often occurs in aging joints especially the knees, which take relentless pounding throughout our lives , there can be hell to pay.
Bone rubs against bone, inflammation ensues, and the pain can be debilitating. What our joints need preferably long before this scenario has had a chance to occur is an abundant supply of proteoglycans in order to maintain healthy cartilage. Whereas glucosamine sulfate is a single chemical compound, chondroitin sulfate is actually a mixture of closely related compounds, consisting mainly of two forms called chondroitin 4-sulfate and chondroitin 6-sulfate—a combination called chondroitin 4,6-sulfates for short.
Some researchers believe that the beneficial effects of chondroitin sulfate supplements may depend in part on the ratio of the 4-sulfate to the 6-sulfate in the mixture, with a preference for a ratio.
Despite abundant evidence of the safety and efficacy of glucosamine and chondroitin, however, many physicians who may not be familiar with the literature on them are skeptical, because they tend to be skeptical of supplements in general. The literature keeps on coming, however, and these arthritis-fighting agents are sure to become more widely accepted by mainstream medicine as time goes on. The latest study from the Belgian scientists actually, two 3-year studies, conducted as randomized, double-blind, placebo-controlled trials, and published in one paper shows again why glucosamine should be an integral part of every treatment plan for patients with OA.
This is the population most affected by OA. The results were most gratifying. After 3 years, the women who had been taking glucosamine sulfate showed no narrowing of the joint-space width in their knees—indicating no progression of the disease—whereas the women on placebo had a narrowing of 0.
Women in the glucosamine sulfate group reported improvements in pain and mobility, but not in stiffness. I know all too well how frustrating it can be when it comes to educating those who are not well versed in alternative medicine about the significant benefits that many types of supplements can have in combating debilitating illnesses, such as osteoarthritis. Erosive osteoarthritis EOA of the hands causes significant inflammation and pain in its victims, and it can severely limit their ability to perform even the most basic tasks of everyday life.
As with OA of the knees, conventional medicine can offer pain relief, but no real protection against progression of the disease. Studies have shown, however, that chondroitin may decrease the rate of progression of the disease in addition to providing symptomatic relief. In a recent study, researchers in Italy gave patients with EOA of the hands 22 women and 2 men, average age 53 either mg of naproxen a commonly used NSAID or naproxen plus mg of chondroitin sulfate, daily; both groups took naproxen when necessary for pain relief.
All the patients in this study showed progressive worsening of their EOA, with increases in the number of joints affected, but the rate of worsening was slightly slower in those taking chondroitin sulfate. On the other hand, the global assessment of disease activity, carried out by the patients and the physicians, showed no changes from baseline in the treated group, but a significant worsening in the untreated group.
These products are not intended to diagnose, treat, cure, or prevent any disease. Postmenopausal Women Benefit from Glucosamine. Edward R. Rosick As the only practitioner of complementary and alternative medicine in a multicenter practice in central Pennsylvania an area not known, at least in terms of its medical community, for embracing change , it can be frustrating to try to educate my colleagues on the usefulness of supplements in maintaining optimal health. Osteoarthritis—Disabler of Millions Osteoarthritis OA is one of the most common and debilitating diseases to afflict middle-aged and elderly people.
Scientific Evidence for Glucosamine and Chondroitin Piles Up In the field of nutritional supplements, few substances have been as well documented for their intended purpose as glucosamine and chondroitin.
The authors stated, Results of the present study suggest that long-term oral administration of glucosamine sulfate for 3 years can delay the natural symptomatic and structural course of knee osteoarthritis in postmenopausal women.
A Little Knowledge Is a Wonderful Thing I know all too well how frustrating it can be when it comes to educating those who are not well versed in alternative medicine about the significant benefits that many types of supplements can have in combating debilitating illnesses, such as osteoarthritis.
References McAlindon T. Glucosamine for osteoarthritis: dawn of a new era? The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial.
Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Naturocetic glucosamine and chondroitin sulfate compounds as structure-modifying drugs in the treatment of osteoarthritis. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.
Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies.
A two-year study of chondroitin sulfate in erosive osteoarthritis of the hands: behavior of erosions, osteophytes, pain, and hand dysfunction. Rosick is an attending physician and clinical assistant professor of medicine at Pennsylvania State University, where he specializes in preventive and alternative medicine. Sign up for our Newsletter. Powered by Shopify.
How Much Glucosamine Chondroitin Should You Take?
Glucosamine sulphate and glucosamine hydrochloride are nutritional supplements. Animal studies have found that glucosamine can both delay the breakdown of and repair damaged cartilage. The results for the use of glucosamine for osteoarthritis are mixed and the size of the effect is modest.
Glucosamine and chondroitin are structural components of cartilage, the tissue that cushions the joints. Both are produced naturally in the body. They are also available as dietary supplements. Researchers have studied the effects of these supplements, individually or in combination, on osteoarthritis, a common type of arthritis that destroys cartilage in the joints.
Supplement used for joint pain may reduce risk of heart disease
Glucosamine plays a vital role in building cartilage, and many people take it as a supplement to treat arthritis and osteoarthritis. It occurs naturally in the fluid around the joints, in animal bones, bone marrow, shellfish, and fungi. Glucosamine, especially glucosamine sulfate, is extracted from the shells of shellfish to make dietary supplements. A synthetic form is made in laboratories, also. In this article, we explain what glucosamine is, why it is taken as a supplement, and whether there is scientific evidence to prove it is effective. We also discuss any side effects and warnings that come with glucosamine. In some dietary supplements, glucosamine may be combined with other ingredients, including chondroitin sulfate, MSM, or shark cartilage.
Does Glucosamine Work? Benefits, Dosage and Side Effects
Many of us live with joint pain; osteoarthritis affects 1 in 10 people in the UK, and many also suffer injuries from sports or accidents. So we tested nine glucosamine supplement brands readily available in the UK, to see whether they contained the amount of glucosamine claimed on the bottle. Dr Cristina Legido-Quigley and her team at Kings College London's Institute of Pharmaceutical Science undertook that analysis, and their tests revealed some surprising discrepancies. There have been countless trials on glucosamine to see whether it helps our joints, and they often compare glucosamine with painkillers or placebo pills, to see which treatment seems to relieve pain more. Some of these studies found glucosamine seemed to help patients, others found it was no better than a placebo pill in relieving pain.
Patients should always consult a health professional before changing their diet or taking any over-the-counter drugs or nutritional supplements also known as dietary supplements or natural supplements. Only patients who have been diagnosed with osteoarthritis by a health professional and have had other possible causes for their back pain ruled out are candidates for glucosamine and chondroitin sulfate supplements. Patients should inform their physician of any other medications they are taking and of their medical history before taking any type of dietary supplement. See Osteoarthritis Complete Treatment Guide.
Medically reviewed by Drugs. Last updated on Oct 30, Scientific Name s : 2-aminodeoxyglucose.
Glucosamine is a natural substance found in cartilage. In the US, it is sold as a dietary supplement and promoted to reduce osteoarthritis pain. It is generally safe and well-tolerated. However, strong scientific evidence showing that it actually works is lacking and dietary supplements are not regulated in the same rigorous manner as medications. Osteoarthritis is a painful joint disorder that affects about 27 million adults in the US.
Glucosamine: Should I try it?
Back to Food and diet. Researchers analysed the diet and lifestyle of almost half a million adults aged 40 to 69 in the UK, and followed them up for an average of 7 years. Some people take glucosamine for joint pain, but it's no longer prescribed for this on the NHS because there's a lack of evidence that it works. The researchers said it may reduce inflammation, which is one factor in the development of heart disease. This was an observational study, which means we do not know for sure that glucosamine was the reason why fewer people taking it had heart disease or stroke.
Joint health concerns affect millions of Americans each year. Weight, genetics and occupational strains play a role, but joint health concerns are more prevalent in older adults because aging affects your joints. Glucosamine is one of the most popular joint-health supplements on the market. While your body produces its own natural supply, many people turn to dietary supplements to help maintain higher levels of glucosamine to support joints and help protect cartilage from the effects of aging.
Glucosamine is a natural compound found in cartilage — the tough tissue that cushions joints. In supplement form, glucosamine is harvested from shells of shellfish or made in a lab. There are several forms of glucosamine, including glucosamine sulfate, glucosamine hydrochloride and N-acetyl glucosamine. These supplements are not considered interchangeable.
Glucosamine is a dietary supplement that is often combined with another supplement, chondroitin , to treat osteoarthritis. Glucosamine is made from the shells of shellfish and chondroitin is derived from cow trachea. Evidence published in the New England Journal of Medicine has suggested that glucosamine alone or combined with chondroitin can help relieve osteoarthritis pain in a subgroup of people with moderate to severe knee osteoarthritis. Supplements advertised for improved joint health can be confusing and even downright misleading.
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Glucosamine is a naturally occurring compound that is chemically classified as an amino sugar 1. It serves as a building block for a variety of functional molecules in your body but is primarily recognized for developing and maintaining cartilage within your joints 1. Glucosamine is also found in some animal and other non-human tissues, including shellfish shells, animal bones and fungi. Supplemental forms of glucosamine are often made from these natural sources 2. Glucosamine is frequently used to both treat and prevent joint disorders, such as osteoarthritis.
Кармен. Ту, что работает в столовой. Бринкерхофф почувствовал, как его лицо заливается краской. Двадцатисемилетняя Кармен Хуэрта была поваром-кондитером в столовой АН Б.